Y-320

Description: Y-320 is a novel, potent and orally bioactive, phenylpyrazoleanilide immunomodulator, which inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 NM. In type II collagen-induced arthritis (CIA) mice, oral administration of Y-320 (0.3-3 mg/kg) reduced IL-17 mRNA expression and significantly inhibited the development of joint destruction and arthritis. The combination of Y-320 with anti-murine tumor necrosis factor-α (TNF-α) monoclonal antibody exhibited a synergistic effect. In cynomolgus monkeys, Y-320 (0.3-1 mg/kg) relieved CIA. These results suggested that Y-320 could be a useful candidate for therapy of rheumatoid arthritis (RA).