Disulfiram

Description: Disulfiram (Disulfan; NSC 190940; Dicupral; Disetil; NSC190940; Tetraethylthiuram disulfide; TETD) is a potent and specific inhibitor of aldehyde-dehydrogenase (ALDH1) that is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. The mechanism of action of disulfiram is to block the metabolic processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase (coverts acetaldehyde to acetic acid), thus causing unpleasant effects when even a small amount of alcohol is consumed.