Trolamine salicylate ester

Description: Trolamine salicylate (ester) is a salicylate ester with Trolamine. Trolamine salicylate ester may have better skin penetration as compared to Trolamine salicylate salt. The penetration of active ingredients from topically applied anti-inflammatory pharmaceutical products into tissues below the skin is the basis of their therapeutic efficacy. References: Sajjadi P, Khodayar MJ, Sharif Makhmalzadeh B, Rezaee S. Percutaneous absorption of salicylic Acid after administration of trolamine salicylate cream in rats with transcutol(®) and eucalyptus oil pre-treated skin. Adv Pharm Bull. 2013;3(2):295-301. doi: 10.5681/apb.2013.048. Epub 2013 Aug 20. PubMed PMID: 24312851; PubMed Central PMCID: PMC3848229.