Cytarabine 5′-monophosphate

药理：Cytarabine 5′-monophosphate (ara-CMP) is an active metabolite of the nucleoside analog cytarabine .1 It is formed from cytarabine by deoxycytidine kinase.2 ara-CMP is incorporated into DNA by DNA polymerase α, which slows the rate of DNA synthesis by approximately 2,000-fold in a cell-free assay.3 It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae when used at a concentration of 15 mM.4 ara-CMP (3.5-75.1mg/kg) improves survival in an L1210 murine leukemia model.5

溶解度：Water: soluble