(-)-Physostigmine (salicylate)

药理：(-)-Physostigmine is an alkaloid that has been found in Calabar beans and a cholinergic agent.1,2 It inhibits acetylcholinesterase (AChE; IC50 = 0.67 nM).2 (-)-Physostigmine (10 µM) inhibits ChE and increases vagal stimulation-induced ACh output in isolated chicken heart.3 In vivo, (-)-physostigmine (200 and 400µg/kg) induces decentralized lower eyelid contractions and increases blood pressure in anesthetized rats.4

溶解度：DMF: 30mg/ml,DMSO: 10mg/ml,Ethanol: 1mg/ml,PBS (pH 7.2): 1mg/ml